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Brookhaven Instruments protein database bank (pdb)
Protein Database Bank (Pdb), supplied by Brookhaven Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/protein+database+bank+(pdb)/protein+database++pdb/pm38994930-54-16-21
Average 90 stars, based on 1 article reviews
protein database bank (pdb) - by Bioz Stars, 2026-09
90/100 stars

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Article Title: A MOLECULAR MODELLING APPROACH FOR STRUCTURE-BASED VIRTUAL SCREENING AND IDENTIFICATION OF NOVEL ISOXAZOLES AS POTENTIAL ANTIMICROBIAL AGENTS AGAINST S. AUREUS
Article Snippet: X-ray crystallographic structures of the four target proteins of S. aureus were downloaded from the Protein Data bank (extracted from the Brookhaven Protein Database http://www.rcsb.org/pdb) and used for docking studies.

Article Title: Analysis of Virus-Specific B Cell Epitopes Reveals Extensive Antigen Degradation Prior to Recognition.
Article Snippet: For linear B cell epitopes, the 3D structure coordinates of protein antigens were obtained from the Protein Database Bank (PDB) at Brookhaven [17], according to the relevant PDB codes in NCBI protein records.

Article Title: Supramolecular synthon hierarchy in cyclopropyl-containing peptide-derived compounds
Article Snippet: Furthermore, in the Brookhaven RCSB Protein Data Bank (PDB database, https://www.rcsb.org/pdb/), 814 structures with cyclopropyl scaffolds have been deposited so far.

Article Title: Discovery of novel tricyclic pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amine derivatives as VEGFR-2 inhibitors.
Article Snippet: Accepted Manuscript Discovery of novel tricyclic pyrido[3’,2’:4,5]thieno[3,2-d]pyrimidin-4-amine derivatives as VEGFR-2 inhibitors Yasmine M. Abdel Aziz, Mohamed M. Said, Hosam A. El Shihawy, Khaled A.M. Abouzid PII: S0045-2068(15)00025-5 DOI: http://dx.doi.org/10.1016/j.bioorg.2015.03.004 Reference: YBIOO 1799 To appear in: Bioorganic Chemistry Received Date: 22 February 2015 Please cite this article as: Y.M.. Abdel Aziz, M.M.. Said, H.A.

Article Title: Molecular modeling studies and synthesis of novel methyl 2-(2-(4-oxo-3-aryl-3,4-dihydroquinazolin-2-ylthio)acetamido)alkanoates with potential anti-cancer activity as inhibitors for methionine synthase.
Article Snippet: The atomic coordinates for the polypeptide segments of MTHF and Hcy binding domains of MetS enzyme extracted from human liver were obtained from the protein bank database PDB (Brookhaven protein database (PDB: 1Q8J)).

Article Title: A supramolecular self-assembly of peptide-derived compounds via 1,5-disubstituted tetrazole-based supramolecular synthons: An experimental and computational study
Article Snippet: The tetrazole moiety is a versatile scaffold in medicinal chemistry due to its specific structure and essential roles in biosciences.. Here, a supramolecular behavior of newly synthesized benzyl 2-[5-(benzyloxycarbonylaminomethyl)tetrazol-1-yl)-3-phenyl-propanoate, 1, was studied by single-crystal X-ray crystallography and computational techniques, and compared with 21 structurally diversified 1,5-disubsituted tetrazole-containing peptidederived structures, retrieved from the Cambridge Structure Database, providing a library of tetrazole-based Hbonding synthons reported for the first time.. Hirshfeld surface analysis, followed by the enrichment ratios, demonstrates that the supramolecular assembly of this class of compounds was controlled mainly by O...H, N...H, C...H and π-stacking interactions.

Article Title: Alpha-amylase variants
Article Snippet: The 3D structural model for Bacillus sp. no. 707 α-amylase has a Protein Database Brookhaven PDB/RSCB Protein Data Bank Accession Number of 1 WPC.

Mutagenesis:

Article Title: A click chemistry approach for the synthesis of mono and bis aryloxy linked coumarinyl triazoles as anti-tubercular agents.
Article Snippet: A series of mono and bistriazole-coumarin hybrids 6a-u and 9a-f have been synthesized using 4-(azidomethyl)-2H-chromen-2-ones 5a-i and aryl propargyl ethers 2a-c and 8 employing Click chemistry modified protocol for Azide-Alkyne cycloadditions(CuAAC).. Anti-tubercular screening showed moderate activity for mono aryloxy compounds 6a-u with MIC 50-100 μg/mL, whereas the bis compounds 9a-f were more effective with MICs between 0.2-12.5 μg/mL.. Molecular modeling and 3D-QSAR measurements using CoMFA and Topomer CoMFA further supported the observed results.



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